This process results in the formation of two new DNA joints coding joints which contain the coding information, and signal joints which contain the two recombination signal sequences. ![]() the rearrangement process is targeted by simple DNA sequence elements (recombination signal sequences, RSS) found immediately adjacent to all functional immune receptor gene segments and involves two double-stranded DNA cuts and subsequent re-ligations.V(D)J rearrangement is the molecular mechanism b y which distinct gene segments (V, D, and J) are joined to form the coding sequences of immunoglobulin (Ig) and T cell receptor (TCR) variable regions.More specifically, the present invention relates to the mutation of a DNA-dependent protein kinase protein which results in equine severe combined immunodeficiency and a diagnostic test to identify carriers of the mutation. the present invention relates generally to the fields of molecular genetics and veterinary medicine.C12Q2600/156- Polymorphic or mutational markers.C12Q2600/00- Oligonucleotides characterized by their use.primers or probes for diseases caused by alterations of genetic material C12Q1/6883- Nucleic acid products used in the analysis of nucleic acids, e.g.C12Q1/6876- Nucleic acid products used in the analysis of nucleic acids, e.g.C12Q1/68- Measuring or testing processes involving enzymes, nucleic acids or microorganisms Compositions therefor Processes of preparing such compositions involving nucleic acids.C12Q1/00- Measuring or testing processes involving enzymes, nucleic acids or microorganisms Compositions therefor Processes of preparing such compositions.C12Q- MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS COMPOSITIONS OR TEST PAPERS THEREFOR PROCESSES OF PREPARING SUCH COMPOSITIONS CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES.C07H21/00- Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g.C07H- SUGARS DERIVATIVES THEREOF NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS.C12N9/1205- Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g.C12N9/12- Transferases (2.) transferring phosphorus containing groups, e.g.C12N9/00- Enzymes Proenzymes Compositions thereof Processes for preparing, activating, inhibiting, separating or purifying enzymes.C12N- MICROORGANISMS OR ENZYMES COMPOSITIONS THEREOF PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS MUTATION OR GENETIC ENGINEERING CULTURE MEDIA.C12- BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION OR GENETIC ENGINEERING. ![]() Assignors: THE UNIVERSITY OF TEXAS SYSTEM Anticipated expiration legal-status Critical Status Expired - Lifetime legal-status Critical Current Links GOVERNMENT CONFIRMATORY LICENSE (SEE DOCUMENT FOR DETAILS). OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT reassignment NATIONAL INSTITUTES OF HEALTH (NIH), U.S. ![]() Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Application filed by University of Texas System filed Critical University of Texas System Priority to US09/407,562 priority Critical patent/US6294334B1/en Application granted granted Critical Publication of US6294334B1 publication Critical patent/US6294334B1/en Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), U.S. Original Assignee University of Texas System Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.) Meek Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Expired - Lifetime Application number US09/407,562 Inventor Katheryn D. Google Patents Genetic test for equine severe combined immunodeficiency diseaseÄownload PDF Info Publication number US6294334B1 US6294334B1 US09/407,562 US40756299A US6294334B1 US 6294334 B1 US6294334 B1 US 6294334B1 US 40756299 A US40756299 A US 40756299A US 6294334 B1 US6294334 B1 US 6294334B1 Authority US United States Prior art keywords leu ser glu lys val Prior art date Legal status (The legal status is an assumption and is not a legal conclusion. Google Patents US6294334B1 - Genetic test for equine severe combined immunodeficiency disease US6294334B1 - Genetic test for equine severe combined immunodeficiency disease
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